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Today's college football lineup brings excitement with 16 of the top 25 teams in action. Check out the full schedule below with odds & picks. Week 10 promises key matchups, including two top-10 teams facing tough road games.

One of those challenges is for No. 4 Ohio State, heading to Beaver Stadium to face No. 3 Penn State in a high-stakes, top-five showdown at 12 p.m. ET on Fox's Big Noon Kickoff. Later in prime time, No. 10 Texas A&M takes on South Carolina at 7:30 p.m. ET on ABC, adding more drama to the evening slate.


Since 2021, Penn State has struggled against elite Big Ten teams, going 0-6 against Ohio State and Michigan, while boasting a strong 35-5 record against other opponents. Ohio State has dominated their recent meetings with Penn State, winning seven in a row and 11 of the last 12 matchups, each victory coming by a margin of 8 to 13 points.

Following a loss to Oregon, Ohio State urgently needs this win to stay in the College Football Playoff race. With a talent edge, Ryan Day's squad is set to continue their winning streak against the Nittany Lions. Take Ohio State ATS

Picks NCAAF
Spread
Money
Total
8 picks 7:00 PM
-19.0 -115
-1200
O52.5 -110
19.0 -105
730
U52.5 -110
6 picks 7:00 PM
-2.0 -110
-130
O52.0 -109
2.0 -110
110
U52.0 -110
Picks NCAAF
Spread
Money
Total
4 picks 8:00 PM
7.5 -110
245
O57.0 -110
-7.5 -110
-300
U57.0 -110
4 picks 8:00 PM
0.0 -110
-114
O62.5 -110
0.0 -110
-104
U62.5 -110
Picks NCAAF
Spread
Money
Total
2 picks 12:00 PM
-7.0 -110
-270
O49.0 -110
7.0 -110
223
U49.0 -110
3 picks 3:30 PM
14.0 -106
457
O49.0 -110
-14.0 -116
-616
U49.0 -110
1 picks 7:00 PM
3.0 -110
130
O55.5 -110
-3.0 -110
-153
U55.5 -110